d-alpha-MSH Heavy
SYSMEH-[U-13C9,15N-Phe]-RWGKPV-amide
Description
Application Data
Description
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Alpha-melanocyte stimulating hormone (α-MSH) is a non-selective agonist of melanocortin receptors involved in metabolic and immune homeostasis. The phenylalanine residue at position 7 is isotopically labelled with carbon-13 (9) and nitrogen-15 (1).
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1301312 Molecular Weight 1631.8 Sequence (one letter code) SYSMEH-[U-13C9,15N-Phe]-RWGKPV-amide
Sequence (three letter code) H-Ser-Tyr-Ser-Met-Glu-His-[U-13C9,15N-Phe]-Arg-Trp-Gly-Lys-Pro-Val-NH2
Purity >95% Storage -20°C References Vecsernyes et al (2017) Alpha–Melanocyte-stimulating Hormone Induces Vasodilation and Exerts Cardioprotection Through the Heme-Oxygenase Pathway in Rat Hearts. J. Cardiovasc. Pharmacol. 69(5) 286 PMID: 28195947
Taylor (2013) Alpha-Melanocyte Stimulating Hormone (α-MSH) Is a Post-Caspase Suppressor of Apoptosis in RAW 264.7 Macrophages. PLoS ONE 8(8) e74488 PMID: 24009773
Capsoni et al (2015) α-Melanocyte-stimulating-hormone (α-MSH) modulates human chondrocyte activation induced by proinflammatory cytokines. BMC Musculoskelet. Disord. 16(1) PMID: 26093672
Manufactured in: United Kingdom Alpha-melanocyte stimulating hormone (α-MSH) is a melanocortin family neuropeptide which plays important roles in metabolic and immune homeostasis. It is formed from the cleavage of adrenocorticotropic hormone, the cleavage product of proopiomelanocortin hormone. α-MSH is expressed ubiquitously to varying degrees in a wide variety of cells including the hypothalamus, monocytes and retinal pigment epithelial cells. α-MSH is a non-selective agonist of melanocortin receptors.
α-MSH is a suppresser of inflammation from both innate and adaptive immune pathways, it is involved in hair and skin pigmentation (through MC1 receptor activation), has reproductive functions, cardio protective functions and regulates food intake and energy metabolism.
The phenylalanine residue at position 7 is isotopically labelled with carbon-13 (9) and nitrogen-15 (1).