[Cys]-Galanin (1-30) Human

[Cys]-GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS-acid

  • Description

  • Application Data

Description

Galanin (1-30) with an N-terminal cysteine is included for site-specific conjugation;  galanin is a widely distributed neuropeptide with a wide variety of roles, including energy homeostasis and mental health.

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Application Data

Catalogue number crb1001479
Molecular Weight 3258.6
Sequence (one letter code)

[Cys]-GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS-acid

Sequence (three letter code)

H-Cys-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser-OH

Purity >95%
References

Weinshenker and Holmes (2016) Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin. Brain Res. 1641 320.

Laque et al., (2013). Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action. Am. J. Physiol-Endocrinol. Metab., 304(9): E999. doi: 10.1152/ajpendo.00643.2012.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Galanin (1-30) is an endogenous neuropeptide with endocrine, metabolic and behavioural effects. Galanin has a role in intestinal smooth muscle contraction, insulin and somatostatin release, and synaptic neurotransmission.

Galanin is widely distributed in the central nervous, peripheral, and endocrine systems. Galanin’s overarching function is as an inhibitory, hyper-polarizing neuromodulator for classical neurotransmitters like acetylcholine and serotonin. Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the Gαi/o pathway; receptor activation leads to a cellular influx of K+. Each receptor has been associated with neurological diseases such as GalR3 and epilepsy.

Galanin protects against various physiological insults in vitro, including excitotoxicity and β-amyloid toxicity. Changes in galanin have been widely studied concerning Alzheimer’s disease, and galaninergic neurons are spared in late-stage Alzheimer’s relative to non-galaninergic neurones.

Galanin (1-30) has been used as an agonist for the GalR2 receptor in vitro for calcium mobilisation assays to understand the role Galanin/GalR2 play in multiple sclerosis.

An N-terminal cysteine residue has been included on the galanin (1-30) peptide to allow ease of site-specific conjugation to various molecules.

[Cys]-Galanin (1-30) Human

Cat No.Pack SizePriceQty.
1mg£170.00
0.5mg£110.00
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