Cys(BDP630/650)-Galanin (1-30) Human

[Cys(BDP630/650)]-GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS-acid

  • Description

  • Application Data

Description

Galanin (1-30) is a neuropeptide with a wide variety of roles, including energy homeostasis and mental health; an N-terminal borondipyrromethene (BDP) (630/650) fluorophore and cysteine for conjugation reactions are attached.

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Application Data

Catalogue number crb1101478
Molecular Weight 3830.8
Sequence (one letter code)

[Cys(BDP630/650)]-GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS-acid

Sequence (three letter code)

[Cys(BDP630/650)]-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-
Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser-OH

Modifications Where BDP 630/650 maleimide is CAS 2183473-31-4
Purity >95%
cas 119418-04-1
Storage -20°C
References

Laque et al., (2013). Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action. Am. J. Physiol-Endocrinol. Metab., 304(9): E999. doi: 10.1152/ajpendo.00643.2012.

Zhong et al., (2021). Cucurbit [n] uril-immobilized sensor arrays for indicator-displacement assays of small bioactive metabolites. ACS Appl. Nano Mater., 4(5): 4676. doi: 10.1021/acsanm.1c00293.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Galanin (1-30) (human) is an endogenous neuropeptide with endocrine, metabolic and behavioural effects. Galanin has a role in intestinal smooth muscle contraction, insulin and somatostatin release, and synaptic neurotransmission.

Galanin is widely distributed in the central nervous, peripheral, and endocrine systems. Galanin’s overarching function is as an inhibitory, hyper-polarizing neuromodulator for classical neurotransmitters like acetylcholine and serotonin. Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the Gαi/o pathway. Activation of the receptor leads to a cellular influx of K+. Each receptor has been associated with neurological diseases such as GalR3 and epilepsy.

Galanin protects against various physiological insults in vitro, including excitotoxicity and β-amyloid toxicity. Changes in galanin have been widely studied in Alzheimer’s disease, and galaninergic neurons are spared in late-stage Alzheimer’s relative to non-galaninergic neurones.

Galanin (1-30) has been used as an agonist for the GalR2 receptor in vitro for calcium mobilisation assays to understand the role Galanin/GalR2 play in multiple sclerosis.

Galanin (1-30) is provided with an N-terminal borondipyrromethene (BDP) fluorophore (630/650), excitation/ emission 628/642nm. It offers a relatively long fluorescence time and high quantum yield as a fluorophore. BDP630/650 is highly suited to in vivo cell imaging, co-localisation imaging and dynamic organelle fusion. Galanin (1-30) is provided with an N-terminal cysteine residue that allows site-specific conjugation. Cambridge Research Biochemicals is a custom peptide provider. If you desire an alternative dye, please contact us to request a custom synthesis.

Cys(BDP630/650)-Galanin (1-30) Human

Cat No.Pack SizePriceQty.
0.5mg£270.00
1mg£320.00
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