Sequence from CRAMP, has potent anti-bacterial activity against Gram-positive and Gram-negative bacterial strains with no haemolytic activity
Catalogue number crb1000041 Molecular Weight 2147.61 Sequence (one letter code) GEKLKKIGQKIKNFFQKL-acid Sequence (three letter code) H-Gly-Glu-Lys-Leu-Lys-Lys-Ile-Gly-Gln-Lys-Ile-Lys-Asn-Phe-Phe-Gln-Lys-Leu-OH Molecular Weight 2147.61 Purity >95% Storage - 20 ° C References
Horibe et al (2013) Roles of cathelicidin-related antimicrobial peptide in murine osteoclastogenesis. Immunology 40(3) 344 PMID: 23826736
Wertenbruch et al (2015) The Anti-Microbial Peptide LL-37/CRAMP Is Elevated in Patients with Liver Diseases and Acts as a Protective Factor during Mouse Liver Injury. Digestion 91(4) 307 PMID: 25998843
Cathelicidin-related anti-microbial peptide (CRAMP), is the mouse homologue of the human LL-37 antimicrobial peptide and shares 67% sequence identity with LL-37.
CRAMP-18 is the anti-bacterial sequence derived from CRAMP, it possesses potent anti-bacterial activity against Gram-positive and Gram-negative bacterial strains with no haemolytic activity. As well as displaying direct anti-microbial activity, CRAMP-18 also binds to lipopolysaccharide (LPS) to neutralise LPS activity.
CRAMP is a cationic peptide, encoded for by the Camp gene and is highly expressed in bone marrow. Its expression is up-regulated by infectious and inflammatory signals and it is secreted by cells such as neutrophils epithelial cells and macrophages