Click PTD-5

4-Pentynyl-RRQRRTSKLMKR-amide

  • Description

  • Application Data

Description

PTD-5 is a cell-penetrating peptide (CPP) labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide).

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Application Data

Catalogue number crb1000129
Molecular Weight 1694.0
Sequence (one letter code)

4-Pentynyl-RRQRRTSKLMKR-amide

Sequence (three letter code)

4-Pentynyl-RRQRRTSKLMKR-amide 4-Pentynyl-Arg-Arg-Gln-Arg-Arg-Thr-Ser-Lys-Leu-Met-Lys-Arg-NH2

Purity >95%
Storage -20°C
References

Li et al., (2013). Click chemistry in peptide-based drug design. Molecules, 18(8): 9797. doi: 10.3390/molecules18089797.

Reinhardt and Neundorf (2016). Design and application of antimicrobial peptide conjugates. Int. J. Mol. Sci., 17(5): 701. doi: 10.3390/ijms17050701.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

protein transduction domain PTD-5 is a cell-penetrating peptide (CPP). PTD-5 is well characterised for its ability to carry conjugates into the cell with high efficiency and induce low toxicity. Several papers have demonstrated the efficacy of PTD-5 as a CPP; PTD-5 was also conjugated to KLA to produce a pro-apoptotic peptide named DP1 which is selective for mitochondrial and bacterial membranes.

PTD-5 is labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide). Azide-alkyne cycloaddition has become the most popular Click reaction. Alkyne-PTD-5 allows various applications, particularly for protein conjugation, modification, and drug delivery.

Click PTD-5

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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