Click PTD-5
4-Pentynyl-RRQRRTSKLMKR-amide
Description
Application Data
Description
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PTD-5 is a cell-penetrating peptide (CPP) labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide).
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1000129 Molecular Weight 1694.0 Sequence (one letter code) 4-Pentynyl-RRQRRTSKLMKR-amide
Sequence (three letter code) 4-Pentynyl-RRQRRTSKLMKR-amide 4-Pentynyl-Arg-Arg-Gln-Arg-Arg-Thr-Ser-Lys-Leu-Met-Lys-Arg-NH2
Purity >95% Storage -20°C References Li et al., (2013). Click chemistry in peptide-based drug design. Molecules, 18(8): 9797. doi: 10.3390/molecules18089797.
Reinhardt and Neundorf (2016). Design and application of antimicrobial peptide conjugates. Int. J. Mol. Sci., 17(5): 701. doi: 10.3390/ijms17050701.
Manufactured in: United Kingdom protein transduction domain PTD-5 is a cell-penetrating peptide (CPP). PTD-5 is well characterised for its ability to carry conjugates into the cell with high efficiency and induce low toxicity. Several papers have demonstrated the efficacy of PTD-5 as a CPP; PTD-5 was also conjugated to KLA to produce a pro-apoptotic peptide named DP1 which is selective for mitochondrial and bacterial membranes.
PTD-5 is labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide). Azide-alkyne cycloaddition has become the most popular Click reaction. Alkyne-PTD-5 allows various applications, particularly for protein conjugation, modification, and drug delivery.