Click Maier8
4-Pentynyl-GKKALKLAAKLLKK-amide
Description
Application Data
Description
-
Maier8 is a cell-penetrating peptide (CPP) labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide).
Application Data
-
Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1000130 Molecular Weight 1588.1 Sequence (one letter code) 4-Pentynyl-GKKALKLAAKLLKK-amide
Sequence (three letter code) 4-Pentynyl-Gly-Lys-Lys-Ala-Leu-Lys-Leu-Ala-Ala-Lys-Leu-Leu-Lys-Lys-NH2
Purity >95% Storage -20°C References Li et al., (2013). Click chemistry in peptide-based drug design. Molecules, 18(8): 9797. doi: 10.3390/molecules18089797.
Maier et al., (2006). Evaluation of basic amphipathic peptides for cellular delivery of antisense peptide nucleic acids. J. Med. Chem., 49(8): 2534. doi: 10.1021/jm051275y.
Manufactured in: United Kingdom Maier8 is a short basic amphipathic peptide that functions as a cell-penetrating peptide (CPP). Maier8 has been studied in comparison to other CPPs and found to be highly efficient at crossing into the cell without causing cytotoxicity. Furthermore, Maier8 has a long half-life which is vital for effective delivery of the conjugate.
Maier8 is labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide). Azide-alkyne cycloaddition has become the most popular Click reaction. Alkyne-Maier8 allows a wide variety of applications, particularly for conjugation, modification, and drug delivery.