Maier8 is a cell-penetrating peptide (CPP) labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide).
Catalogue number crb1000130 Molecular Weight 1588.1 Sequence (one letter code)
Sequence (three letter code)
Purity >95% Storage -20°C References
Li et al., (2013). Click chemistry in peptide-based drug design. Molecules, 18(8): 9797. doi: 10.3390/molecules18089797.
Maier et al., (2006). Evaluation of basic amphipathic peptides for cellular delivery of antisense peptide nucleic acids. J. Med. Chem., 49(8): 2534. doi: 10.1021/jm051275y.
Manufactured in: United Kingdom
Maier8 is a short basic amphipathic peptide that functions as a cell-penetrating peptide (CPP). Maier8 has been studied in comparison to other CPPs and found to be highly efficient at crossing into the cell without causing cytotoxicity. Furthermore, Maier8 has a long half-life which is vital for effective delivery of the conjugate.
Maier8 is labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide). Azide-alkyne cycloaddition has become the most popular Click reaction. Alkyne-Maier8 allows a wide variety of applications, particularly for conjugation, modification, and drug delivery.