Cathepsin D (332-341) Heavy [U-13C5,15N-Val]-STLPAITLK-acid

  • Description

  • Application Data


Cathepsin D degrades proteins and activates precursors of bioactive proteins in pre-lysosomal compartments.

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Application Data

Catalogue number crb1300698
Molecular Weight 1047.7
Sequence (one letter code) [U-13C5,15N-Val]-STLPAITLK-acid
Sequence (three letter code)


Purity >95%
Storage -20°C

Marques et al (2019) Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis. Autophagy 16 (1-15) PMID: 31282275

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments, including substrates of endocytosis, phagocytosis and autophagy. Consequently, cathespin D deficiency leads to a strong impairment of the lysosomal-autophagy machinery.

Mutations in the gene encoding cathespin D, CTSD, are associated with the pathogenesis of several diseases, including breast cancer and Alzheimer’s disease.

Cathepsin D (332-341) Heavy

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