Biotin-PEG2-Claudin-9 is derived from the transmembrane protein Claudin-9 which is a tight junction protein involved in maintaining cell polarity and controlling paracellular ion flux. This peptide contains a covalently bonded N-terminal Biotin tag and a polyethylene glycol spacer (PEG2).
Catalogue number crb1000357 Molecular Weight 2881.5 Sequence (one letter code) Biotin-PEG2-TAHAIIQDFYNPLVAEALKREL-amide Sequence (three letter code)
Purity >95% References
Liu et al (2019) Claudin-9 enhances the metastatic potential of hepatocytes via Tyk2/Stat3 signalling. Turkish J. Gastroenterology 30 (8) 722 PMID: 31418417 Mi
Jeong Kwon et al (2010) Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications. Carcinogenesis 31 (6) 974 DOI: https://doi.org/10.1093/carcin/bgp336
Manufactured in: United Kingdom
Biotin-PEG2-Claudin-9 is derived from the tight junction protein Claudin-9 which is encoded by the CLDN6 gene and can be found within epithelial cell to cell contacts. Structurally, the Claudin family, of which Claudin-9 is a member, are transmembrane proteins containing two extracellular loops and are involved in maintaining cell polarity and controlling paracellular ion flux.
Reduction in the number of Claudins has been associated with tumour formation. This may be due to Claudin’s role in maintaining cell detachment and migration.
Claudin-9 has been shown to be overexpressed in hepatocellular carcinoma (HCC) and has the ability to increase the metastasis of hepatocytes. It further influences the activation of the Stat3 signalling pathway through tyrosine kinase 2. Overall CLDN9 demonstrates itself to be a HCC proto-oncogene.
This peptide has a covalently bonded N-terminal Biotin tag that can be used for detection and purification and contains a polyethylene glycol spacer (PEG2).