Biotin-Influenza A NP (147-155) (H-2Kd)
Biotin-TYQRTRALV-acid
Description
Application Data
Description
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Biotin-Influenza A NP (147-155) (H-2Kd) is an effective cytotoxic T lymphocyte (CTL) epitope, N-terminal biotin.
Application Data
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Data Sheet Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1001751 Molecular Weight 1332.7 Sequence (one letter code) Biotin-TYQRTRALV-acid
Sequence (three letter code) Biotin-Thr-Tyr-Gln-Arg-Thr-Arg-Ala-Leu-Val-OH
Purity >95% References Choi et al., (2020). Non-sterilizing, infection-permissive vaccination with inactivated influenza vaccine reshapes subsequent virus infection-induced protective heterosubtypic immunity from cellular to humoral cross-reactive immune responses. Front. Immunol, 11: 1166. doi: 10.3389/fimmu.2020.01166.
McGee and Huang, (2022). Evolutionary conservation and positive selection of influenza A nucleoprotein CTL epitopes for universal vaccination. J. Med. Virol, 94(6): 2578. doi: 10.1002/jmv.27662.
Manufactured in: United Kingdom Influenza A nucleoprotein (NP) residues 147-155 (TYQRTRALV) is from a conserved region of the nucleoprotein that is positively selected. NP (147-155) is an effective immunodominant CTL epitope MHC allele H-2Kd in mice that can induce an effective antigen-specific immunity. This was validated by HLA binding and cytotoxicity assays in human cells. Immunisation of mice with the NP (147-155) offers protection against a fatal dosage of influenza. In addition, the NP (147-155) epitope can stimulate antigen-specific T cells in T cell assays such as ELISPOT to understand humoral responses to viral infection. Further work with the NP (147-155) epitope can help new flu vaccine design to provide more effective protection. This epitope is provided with a C-terminal biotin sequence for easier purification and detection.