Biotin-Desmoglein-3 DSG3 (50-79) Biotin-E-W-V-KFAKPC*REGEDNSKRNPIAKITSDYQA-acid
Description
Application Data
Description
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Desmoglein-3 DSG3 (50-79) is derived from the pemphigus vulgaris antigen DSG3 and is involved in cell-cell adhesion. Biotin (B7) has been added to the N-terminus.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1000386 Molecular Weight 3705.9 Sequence (one letter code) Biotin-E-W-V-KFAKPC*REGEDNSKRNPIAKITSDYQA-acid Sequence (three letter code) Biotin-Glu-Trp-Val-Lys-Phe-Ala-Lys-Pro-Cys-Arg-Glu-Gly-Glu-Asp-Asn-Ser-Lys-Arg-Asn-Pro-Ile-Ala-Lys-Ile-Thr-Ser-Asp-Tyr-Gln-Ala-OH
Modifications *Cysteine may form disulphide bridges leading to a variable percentage of dimerised product. Purity >95% References Brown et al (2014) Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation. Oncogene 33 2363 Doi: https://doi.org/10.1038/onc.2013.186
Manufactured in: United Kingdom Desmoglein-3 DSG3 (50-79) is derived from the pemphigus vulgaris antigen DSG3 and is involved in cell-cell adhesion. It can exist as non-junctional and junctional and is one of the desmosomal cadherins. Within the epithelial cells non-junctional DSG3 takes part in E-cadherin signalling.
The overexpression of DSG3 has been observed in squamous cell carcinoma and can be used as a biomarker for cervical sentinel lymph nodes. DSG3 in tumours is considered as being pro-metastatic through DSG3’s ability to activate AP-1 and the PKC/Ezrin pathway.
Biotin (B7) has been added to the N-terminus.