Biotin-Desmoglein-3 DSG3 (50-79) Biotin-E-W-V-KFAKPC*REGEDNSKRNPIAKITSDYQA-acid
Desmoglein-3 DSG3 (50-79) is derived from the pemphigus vulgaris antigen DSG3 and is involved in cell-cell adhesion. Biotin (B7) has been added to the N-terminus.
Catalogue number crb1000386 Molecular Weight 3705.9 Sequence (one letter code) Biotin-E-W-V-KFAKPC*REGEDNSKRNPIAKITSDYQA-acid Sequence (three letter code)
Modifications *Cysteine may form disulphide bridges leading to a variable percentage of dimerised product. Purity >95% References
Brown et al (2014) Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation. Oncogene 33 2363 Doi: https://doi.org/10.1038/onc.2013.186
Manufactured in: United Kingdom
Desmoglein-3 DSG3 (50-79) is derived from the pemphigus vulgaris antigen DSG3 and is involved in cell-cell adhesion. It can exist as non-junctional and junctional and is one of the desmosomal cadherins. Within the epithelial cells non-junctional DSG3 takes part in E-cadherin signalling.
The overexpression of DSG3 has been observed in squamous cell carcinoma and can be used as a biomarker for cervical sentinel lymph nodes. DSG3 in tumours is considered as being pro-metastatic through DSG3’s ability to activate AP-1 and the PKC/Ezrin pathway.
Biotin (B7) has been added to the N-terminus.