AVLQSGFR
Description
Application Data
Description
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Octapeptide identified by a docking study that binds to and acts as a competitive inhibitor of the severe acute respiratory syndrome (SARS) coronavirus (CoV) proteinase SARS-CoV Mpro, (3CLpro). It is an effective inhibitor of SARS coronavirus with an EC50 of 2.7 x 10-2 mg/L and shows no detectable toxicity on the host Vero cells.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number d41d8cd98f00 Citations Chou K-C, Wei D-Q & Zhong W-Z (2003) Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS. Biochemical & Biophysical Research Communications 308:148–151. Gan et al (2006) Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase. Peptides 27 622 (https://www.ncbi.nlm.nih.gov/pubmed/16242214) References Chou K-C, Wei D-Q & Zhong W-Z (2003) Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS. Biochemical & Biophysical Research Communications 308:148–151. Gan et al (2006) Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase. Peptides 27 622 (https://www.ncbi.nlm.nih.gov/pubmed/16242214) Octapeptide identified by a docking study that binds to and acts as a competitive inhibitor of the severe acute respiratory syndrome (SARS) coronavirus (CoV) proteinase SARS-CoV Mpro, (3CLpro). It is an effective inhibitor of SARS coronavirus with an EC50 of 2.7 x 10-2 mg/L and shows no detectable toxicity on the host Vero cells.