Ara h 6 (120–131) peanut Allergen ELMNLPQQCNFR-acid

  • Description

  • Application Data

Description

Tryptic peptide from Ara h 6, one of the major peanut allergens

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Application Data

Catalogue number crb1000926
Molecular Weight 1491.7
Sequence (one letter code) ELMNLPQQCNFR-acid
Sequence (three letter code)

H-Glu-Leu-Met-Asn-Leu-Pro-Gln-Gln-Cys-Asn-Phe-Arg-OH

Purity >95%
Storage -20°C
References

Chen et al (2012) Ara h 2 and Ara h 6 Have Similar Allergenic Activity and Are Substantially Redundant. Int. Arch. Allergy Immunol. 160(3) 251 PMID: 23075924

 

Koid et al (2013) Ara h 6 Complements Ara h 2 as an Important Marker for IgE Reactivity to Peanut. J. Agric. Food Chem. 62(1) 206 PMID: 24328145

 

Koppelman et al (2018) Release of Major Peanut Allergens from Their Matrix under Various pH and Simulated Saliva Conditions—Ara h2 and Ara h6 Are Readily Bio-Accessible. Nutrients 10(9) 1281 PMID: 30208580

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Ara h 6 is one of the major allergenic proteins from peanut (Arachis hypogaea) which contains approximately 13 potential allergenic proteins. Ara h 6 is a member of the 2S albumins (conglutinins) belonging to the prolamin superfamily which also includes Ara h 2. 2S albumins contain major food allergens from seeds of many mono‐ and dicotyledon plants and share a common compact structure that renders the proteins highly resistant to proteolysis.

Ara h 6 contains multiple disulphide–bridged cysteine residues, resulting in a tightly coiled, heat-stable, protease resistant core structure that may be important for allergenicity. In mouse models Ara h 2 and Ara h 6 are the main cause of effector responses such as mast cell degranulation and anaphylaxis.

This peptide represents a tryptic peptide of Ara h 6. The phenylalanine residue at position 11 of this peptide is isotopically labelled with carbon-13 (9) and nitrogen-15 (1), giving this peptide a mass increase of 10 compared to the unlabelled peptide.

Ara h 6 (120–131) peanut Allergen

Cat No.Pack SizePriceQty.
0.5mg£95.00
1mg£130.00
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