Apidaecin IB GNNRPVYIPQPRPPHPRL-amide
Description
Application Data
Description
-
Apidaecin IB is an insect derived antimicrobial peptide (AMP). Apidaecin IB mainly possesses activity against gram-negative bacteria.
Application Data
-
Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1000002 Molecular Weight 2107.42 Sequence (one letter code) GNNRPVYIPQPRPPHPRL-amide Sequence (three letter code) H-Gly-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Gln-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2
Purity >95% Storage - 20 ° C References Berthold and Hoffmann (2014). Cellular uptake of apidaecin 1b and related analogs in Gram-negative bacteria reveals novel antibacterial mechanism for proline-rich antimicrobial peptides. Protein Pept. Lett., 21(4): 391.
Gobbo et al., (2002). Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues. J Med Chem., 45(20): 4494. PMID: 12238928.
Manufactured in: United Kingdom Apidaecin IB was isolated from the honeybee Apis mellifera. As a cationic proline-rich antimicrobial peptide (PrAMP), Apidaecin IB shows sequence homology with drosocin but is devoid of any pore-forming activity. Apidaecin IB is most active against gram-negative bacteria, it can navigate the outer membrane to the periplasm and then to the cytoplasm. Apidaecin IB is a non-lytic AMP, the main target of its antimicrobial activity appears to be inhibition of the chaperone heat shock protein DnaK. Toxicity appears to be exclusively to bacteria and thus has been trialled as a treatment for systemic bacterial infections. Numerous analogues and derivatives are being investigated to establish Apidaecin IB’s mode of action and also to improve its functionality.