Antennapedia peptide Arg RQIRIWFQNRRMRWRR-acid
Description
Application Data
Description
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An arginine-rich version of penetratin cell-penetrating peptide (CPP) C-terminal acid, derived from the homeodomain of Antennapedia (Drosophila).
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1000178 Molecular Weight 2358.79 Sequence (one letter code) RQIRIWFQNRRMRWRR-acid Sequence (three letter code) H-Arg-Gln-Ile-Arg-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
Purity >95% References Derossi et al., (1998). Trojan peptides: the penetratin system for intracellular delivery. Trends Cell Biol., 8(2): 84. DOI: https://doi.org/10.1016/S0962-8924(98)80017-2.
Garibotto et al., (2011). Penetratin analogues acting as antifungal agents. Eur J Med Chem., 46(1): 370. PMID: 21093119.
Manufactured in: United Kingdom Identification of cell penetrating conjugates has aided numerous areas of scientific development. The Drosophila transcription factor Antennapedia contains a homeodomain that can be internalised by cells in a receptor-independent mechanism to the cytoplasm and to the nucleus. The key residues for internalisation have been sequenced (RQIKIWFQNRRMKWKK) and used in several studies to aid entry of recombinant proteins into cells.
To further the scope of cell penetrating peptides (CPPs), analogues of penetratin have been generated. This arginine rich acid sequence was made and found to be a strong antimicrobial/antifungal agent while also retaining its CPP properties. The activity was tested against the pathogenic strains Candida albicans, Cryptococcus neoformans, Staphylococcus aureus, and Escherichia coli. The degree of arginine content is linked to the rate of cellular uptake and antimicrobial activity.