Angiotensin II dual Heavy

DR-[U-13C5,15N-Val]-Y-[U-13C6,15N-Ile]-HPF-acid

  • Description

  • Application Data

Description

Angiotensin II is a key peptide of the RAS, upregulated in metabolic disorders and cancers. Valine and isoleucine residues are 13C and 15N labelled.

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Application Data

Catalogue number crb1300308
Molecular Weight 1058.5
Sequence (one letter code)

DR-[U-13C5,15N-Val]-Y-[U-13C6,15N-Ile]-HPF-acid

Sequence (three letter code)

H-Asp-Arg-[U-13C5,15N-Val]-Tyr-[U-13C6,15N-Ile]-His-Pro-Phe-OH

Purity >95%
Storage -20°C
References

Azevedo et al., (2014). Transcriptional Network Analysis Reveals that AT1 and AT2 Angiotensin II Receptors Are Both Involved in the Regulation of Genes Essential for Glioma Progression. PLoS ONE, 9(11): e110934. PMID: 25365520.

Rodrigues-Ferreira et al., (2012). Angiotensin II Facilitates Breast Cancer Cell Migration and Metastasis. PLoS ONE, 7(4): e35667. PMID: 22536420.

Takane et al., (2017). Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure. J. Am. Heart Assoc., 6(4): e004897. PMID: 28428194.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Angiotensin II (Ang-II) is a key signalling peptide of the renin angiotensin system (RAS). The RAS is involved in regulating functions such as blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity is widely studied in relation to lifestyle-related diseases.

Ang-II is produced from angiotensinogen (AGT) via the intermediate angiotensin I (Ang-I). AGTis cleaved by the aspartyl-protease, renin, to produce Ang-I, which is then cleaved by the dicarboxyl-peptidase angiotensin converting enzyme (ACE), which removes a histidine and a leucine, from the C-terminus of Ang-I to form Ang-II.

Ang-II exerts its affect by binding to the G-protein-coupled receptors; Ang-II type 1 (AT1) and Ang-II type 2 (AT2) receptors. Ang-II plays central roles in glucose metabolism and blood pressure. Increased levels of Ang-II have also been associated with Alzheimer’s disease, and certain cancers including oesophageal squamous cell carcinoma (ESCC), brain cancers and breast cancer. The effects of Ang-II appear to be supressed by another branch of the RAS; the ACE2/Ang-(1-7)/Mas pathway.

The valine residue at position 3 and the isoleucine residue at position 5 of this peptide are isotopically labelled with carbon-13 (11) and nitrogen-15 (2), giving this peptide a mass increase of 13 compared to the unlabelled peptide.

Angiotensin II dual Heavy

Cat No.Pack SizePriceQty.
25nmol£220.00
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