Angiotensin II Antipeptide

EGVYVHPV-acid

  • Description

  • Application Data

Description

Angiotensin II antipeptide is a receptor agonist derived from the anti-sense mRNA complementary to the human Ang-II mRNA.

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Application Data

Catalogue number crb1000689
Molecular Weight 898.5
Sequence (one letter code)

EGVYVHPV-acid

Sequence (three letter code)

H-Glu-Gly-Val-Tyr-Val-His-Pro-Val-OH

Purity >95%
cas 121379-63-3
Storage -20°C
References

Huang et al., (2015). Selective electromembrane extraction based on isoelectric point: Fundamental studies with angiotensin II antipeptide as model analyte.    J. Membr. Sci., 481: 115. doi: 10.1016/j.memsci.2015.02.006.

Ying et al., (2000). Effects of angiontensin II antipeptide on ion channels in guinea pig ventricular myocytes. Zhonghua xin xue Guan Bing za zhi, 28(1): 58.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

An angiotensin II (Ang-II) receptor antagonist, the sequence of the angiotensin II anti‑peptide has been derived from the anti-sense mRNA complementary to the human Ang-II mRNA. The anti-peptide shares 50% sequence homology with Ang-II and acts to inhibit some of Ang‑II’s biological activities.

Ang-II is a key signalling peptide of the renin angiotensin system (RAS), which is involved in regulating blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity and is widely studied in relation to lifestyle-related diseases. Ang-II is produced from angiotensinogen (AGT) via the intermediate angiotensin I (Ang-I). AGTis cleaved by the aspartyl-protease, renin, to produce Ang-I, which is then cleaved by the dicarboxyl-peptidase angiotensin converting enzyme (ACE). ACE removes a histidine and a leucine, from the C-terminus of Ang-I to form Ang-II.

Ang-II exerts its affect by binding to the G-protein-coupled receptors; Ang II type 1 (AT1) and Ang II type 2 (AT2) receptors. Ang-II plays central roles in glucose metabolism and blood pressure. Increased levels of Ang-II have also been associated with Alzheimer’s disease, and certain cancers including oesophageal squamous cell carcinoma (ESCC), brain cancers and breast cancer. The effects of Ang-II appear to be supressed by another branch of the RAS; the ACE2/Ang-(1-7)/Mas pathway.

Angiotensin II Antipeptide

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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