Angiotensin I DRVYIHPFHL-acid

  • Description

  • Application Data


Precursor for angiotensin-II (Ang-II) and substrate for angiotensin convertingenzyme (ACE)

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Application Data

Catalogue number crb1000132
Molecular Weight 1296.48
Sequence (one letter code) DRVYIHPFHL-acid
Sequence (three letter code) H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH
Molecular Weight 1296.48
Purity >95%

Chappell (2016) Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute? Am. J. Physiol. Heart Circ. Physiol. 310(2) H137 PMID: 26475588

Hildebrand et al (2013) Proteolytic Processing of Angiotensin-I in Human Blood Plasma. PLoS ONE 8(5) e64027 PMID: 23724017

Sparks et al (2014) Classical Renin-Angiotensin System in Kidney Physiology. Compr. Physiol. 1201 PMID: 24944035

Data Sheet Material Safety Data Sheet (MSDS)

The renin angiotensin system (RAS), consists of many angiotensin peptides involved in regulating functions such as blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity and RAS is widely studied in relation to lifestyle-related diseases.

Angiotensin I (Ang-I), is the first angiotensin to be produced upon activation of the RAS system. It is produced by the cleavage of angiotensinogen (AGT), catalysed by the aspartylprotease, renin. The dicarboxyl-peptidase angiotensin converting enzyme (ACE), then removes two amino acids from the C-terminus of Ang-I to form angiotensin II (Ang-II), and His-Leu.

Ang-I is also converted to Ang-II by chymase, especially in the human heart. The chymase pathway is important in inflammatory conditions.

Angiotensin I

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