Angiotensin 1-7

DRVYIHP-acid

  • Description

  • Application Data

Description

Angiotensin fragment (1-7) is a component of the RAS, opposes actions of Ang-II and has positive outcomes on metabolic disorders.

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Application Data

Catalogue number crb1000803
Molecular Weight 898.5
Sequence (one letter code)

DRVYIHP-acid

Sequence (three letter code)

H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH

Purity >95%
cas 51833-78-4
Storage -20°C
References

Santos and Andrade, (2014). Angiotensin 1-7: A peptide for preventing and treating metabolic syndrome. Peptides, 59: 34. PMID: 25017239.

Karnik et al., (2017). Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: Br. J. Pharmacol., 174(9): 737. PMID: 28194766.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Angiotensin 1-7 (Ang-(1-7)) is a component of the renin angiotensin system RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang1‑7 directly from angiotensin I (Ang-I).

Ang-(1-7) broadly opposes Ang-II actions. Ang-(1–7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders, Ang-(1-7) therefore represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang‑(1-7) exerts its actions via its G-protein-coupled receptor, Mas. This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway.

Angiotensin 1-7

Cat No.Pack SizePriceQty.
1mg£110.00
0.5mg£85.00
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