Angiotensin 1-7 Heavy

DR-[U-13C5,15N-Val]-YIHP-acid

  • Description

  • Application Data

Description

Angiotensin 1-7 is a component of the Renin Angiotensin System (RAS), and opposes actions of Ang-II. Contains 13C and 15N labelled valine residue.

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Application Data

Catalogue number crb1301608
Molecular Weight 904.5
Sequence (one letter code)

DR-[U-13C5,15N-Val]-YIHP-acid

Sequence (three letter code)

H-Asp-Arg-[U-13C5,15N-Val]-Tyr-Ile-His-Pro-OH

Purity >95%
Storage -20°C
References

Santos and Andrade (2014). Angiotensin 1–7: A peptide for preventing and treating metabolic syndrome. Peptides, 59: 34. PMID: 25017239.

Karnik et al., (2017). Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: Br. J. Pharmacol., 174(9): 737. PMID: 28194766.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Angiotensin 1-7 (Ang-(1-7)) is a component of the renin angiotensin system RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang1 7 directly from angiotensin I (Ang-I).

Ang-(1-7) broadly opposes Ang-II actions. Ang-(1–7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders. Ang-(1-7) represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang (1-7) stimulate the secretion of atrial natriuretic peptide (ANP) and exerts its actions via its G protein-coupled receptor, Mas. ANP is part of an antagonistic hormonal system to RAS, which also participates in the regulation of body fluid and electrolytes balance. ANP is mainly released from the atrium, and its release results in natriuresis, anti-hypertension, and anti-proliferation.

This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway. The valine residue of this peptide is universally labelled with carbon-13 and nitrogen-15 stable isotopes, giving a mass increase of 6.

Angiotensin 1-7 Heavy

Cat No.Pack SizePriceQty.
25nmol£220.00
Bulk Quote

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