Angiotensin 1-7 Heavy 25nmol DRVY-[U-13C6,15N-Ile]-HP-acid
Description
Application Data
Description
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Component of the RAS, opposes actions of Ang-II. Contains stable 13C and 15N labelled isoleucine residue.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1300306c Molecular Weight 905.5 Sequence (one letter code) DRVY-[U-13C6,15N-Ile]-HP-acid Sequence (three letter code) H-Asp-Arg-Val-Tyr-[U-13C6,15N-Ile]-His-Pro-OH
Purity >95% Storage -20°C References Santos, S. and Andrade, J. (2014). Angiotensin 1–7: A peptide for preventing and treating metabolic syndrome. Peptides, 59, 34-41. PMID: 25017239
Karnik, S., Singh, K., Tirupula, K. and Unal, H. (2017). Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22. Br J Pharmacol, 174(9), 737-753. PMID: 28194766
Manufactured in: United Kingdom Angiotensin 1-7 (Ang-(1-7)) is a component of the renin angiotensin system RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang1‑7 directly from angiotensin I (Ang-I).
Ang-(1-7) broadly opposes Ang-II actions. Ang-(1–7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders, Ang-(1-7) therefore represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang‑(1-7) exerts its actions via its G-protein-coupled receptor, Mas. This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway.
The isoleucine residue at position 5 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.