Angiotensin 1-5 dual Heavy
DR-[U-13C5,15N-Val]-Y-[U-13C6,15N-Ile]-acid
Description
Application Data
Description
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Angiotensin (1-5) is a biologically active metabolite of Ang-(1-7) with isoleucine residue labelled with stable 13C and 15N isotopes.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1300304 Molecular Weight 677.4 Sequence (one letter code) DR-[U-13C5,15N-Val]-Y-[U-13C6,15N-Ile]-acid
Sequence (three letter code) H-Asp-Arg-[U-13C5,15N-Val]-Tyr-[U-13C6,15N-Ile]-OH
Purity >95% Storage -20°C References Yu et al., (2016). Angiotensin-(1-5), an active mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor. Peptides, 86: 33. PMID: 27660028.
Manufactured in: United Kingdom Angiotensin 1-5 (Ang- (1-5)) is a biologically active metabolite of Ang-(1-7). Its production is catalysed by angiotensin-converting enzyme (ACE). Like Ang-(1-7), Ang-(1-5) stimulates atrial natriuretic peptide (ANP) secretion via the G-protein-coupled receptor, Mas.
The isoleucine residue at position 5 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.