Amylin (1-37) Human


  • Description

  • Application Data


Amylin (1-37) is a peptide hormone also known as islet amyloid polypeptide (IAPP). Amylin is deficient in people with diabetes mellitus; inhibits glucagon secretion and delays gastric emptying.

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Application Data

Catalogue number crb1000269
Molecular Weight 3901.85
Sequence (one letter code)


Sequence (three letter code)

H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-OH (Disulphide bridge Cys2-Cys7)

Aliase Amlintide
Modifications Disulphide bridge Cys2-Cys7
Purity >85%

Singh et al (2015) Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis. Adv. Exp. Med. Biol. 95 PMID: 26149927

Akter et al (2016) Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology. J. Diabetes Res. 2016 1 PMID: 26649319

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Amylin, also known as islet amyloid polypeptide (IAPP), is a peptide hormone which is deficient in patients with diabetes mellitus (DM). Amylin is co-secreted with insulin from the pancreatic β-cells. It inhibits glucagon secretion, delays gastric emptying, and thus acts as a satiety agent.  Amylin peptide is capable of forming aggregates, and pancreatic amyloid plaques are present in 90% of patients with DM. Formation of these plaques may be inhibited by insulin via the formation of heteromolecular complexes. Amylin is also involved in adiposity signalling and body weight regulation.

Amylin is expressed in the human placenta during pregnancy where it may help regulate food intake by both the mother and foetus, and is involved in foetal development of bone, kidneys and pancreas

Amylin (1-37) Human

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