AIP-III 0.5mg

INCDFLL (Thiolactone 3-7)

£170.00
  • Description

  • Application Data

Description

Quorum sensing peptide from S. aureus. Activates agr response, and expression of virulence factors and toxins

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Application Data

Catalogue number crb1001688h
Molecular Weight 818.4
Sequence (one letter code)

INCDFLL (Thiolactone 3-7)

Sequence (three letter code)

H-Ile-Asn-Cys-Asp-Phe-Leu-Leu (Thiolactone 3-7)

Aliase AIP-3, Autoinducing peptide 3
Purity >95%
Storage -20°C
References

Beavis and Novick (1995) Cell density control of staphylococcal virulence mediated by an octapeptide pheromone. PNAS, 92(26) 12055 PMID: 8618843

 

Thoendel et al (2011) Peptide Signaling in the Staphylococci. Chem. Rev. 111(1) 117 PMID: 21174435

Manufactured in: United Kingdom
Material Safety Data Sheet (MSDS)

Auto-inducing peptide (AIP) is a cyclic thiolactone quorum sensing peptide from Staphylococcus aureus which is responsible for activating the agr response. AIP is released from the bacteria and its extracellular concentration is then sensed by a two-component system on the bacterial surface, AgrC and AgrA. AgrC is the membrane histidine kinase receptor and AgrA is a response regulator; upon binding of AIP, AgrC phosphorylates AgrA.

AIP accumulates during growth activating an AgrC and AgrA cascade when it reaches a critical signal level. This cascade activates P2 and P3 promoters which autoactivate the agr system and upregulate RNAIII transcription. RNAIII regulates the expression of virulence factors including toxins, super-antigens, and exo-enzymes.

AgrD is the precursor peptide of AIP, and AgrB is an integral membrane endopeptidase essential to biosynthesize AIP. This AIP system is conserved among many Gram-positive bacteria.

AIP-III 0.5mg

0.5mg
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