AIP-I

YSTCDFIM (Thiolactone 4-8)

  • Description

  • Application Data

Description

AIP-I is a quorum sensing peptide from S. aureus. Activates agr response, and expression of virulence factors and toxins.

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Application Data

Catalogue number crb1000249
Molecular Weight 961.11
Sequence (one letter code)

YSTCDFIM (Thiolactone 4-8)

Sequence (three letter code)

H-Tyr-Ser-Thr-Cys-Asp-Phe-Ile-Met (Thiolactone 4-8)

Aliase AIP-1, Autoinducing peptide 1, AIP1, Agr D1 thiolactone
Purity >95%
cas 200010-29-3
References

Beavis and Novick (1995) Cell density control of staphylococcal virulence mediated by an octapeptide pheromone. PNAS, 92(26) 12055 PMID: 8618843

 

Thoendel et al (2011) Peptide Signaling in the Staphylococci. Chem. Rev. 111(1) 117 PMID: 21174435

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Auto-inducing peptide (AIP) is a cyclic thiolactone quorum sensing peptide from Staphylococcus aureus which is responsible for activating the agr response. AIP is released from the bacteria and its extracellular concentration is then sensed by a two-component system on the bacterial surface, AgrC and AgrA. AgrC is the membrane histidine kinase receptor and AgrA is a response regulator; upon binding of AIP, AgrC phosphorylates AgrA.

AIP accumulates during growth activating an AgrC and AgrA cascade when it reaches a critical signal level. This cascade activates P2 and P3 promoters which autoactivate the agr system and upregulate RNAIII transcription. RNAIII regulates the expression of virulence factors including toxins, super-antigens, and exo-enzymes. Extensive research to identify AIP:AgrC inhibitors aims to find therapeutics against pathogens.

AgrD is the precursor peptide of AIP, and AgrB is an integral membrane endopeptidase essential to biosynthesize AIP. This AIP system is conserved among many Gram-positive bacteria. S. aureus strains are categorized into four groups (I–IV) according to their AIP signal and cognate extracellular receptor, AgrC.  AIP-I has the characteristic five-residue thiolactone ring with a short N-terminal extension. AIP-I has been used to generate a biosensor for the detection of S. aureus in nanomolar range for use in hospital settings.

AIP-I

Cat No.Pack SizePriceQty.
0.5mg£170.00
1mg£220.00
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