• Description

  • Application Data


Selective receptor antagonist to the human cytokine, type 1 interleukin-1 (IL-1)

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Application Data

Catalogue number crb1001289
Molecular Weight 1895.9
Sequence (one letter code) Ac-FEWTPGWYQJYALPL-amide
Sequence (three letter code)


Aliase IL-1ra, Ac-FEWTPGWYQXYALPL-amide
Modifications Where J is unnatural amino acid 2-azetidine-1-carboxylic acid
Purity >95%
cas 185413-30-3
Storage -20°C

Yan et al (2017) Chronic pain and impaired glial glutamate transporter function in lupus-prone mice are ameliorated by blocking macrophage colony-stimulating factor-1 receptors. J. Neurochem. 140(6) 963 PMID: 28072466

Akeson et al (1996) AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J Biol. Chem. 271(48) 30517 PMID: 8940020

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

AF12198 is a selective receptor antagonist to the human cytokine, type 1 interleukin-1 (IL-1) and thus blocks IL-1β signalling. AF12198 can inhibit IL-1-induced IL-8 production by human dermal fibroblasts and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells. AF12198 also blocks IL-1 induction of IL-6 and down regulates IL-6 induction in monkeys. AF12198 does not bind the human type II IL-1 receptor, or the murine type I IL-1 receptor.

IL-1 influences a wide range of immune and inflammatory responses. Sustained expression of even low levels of IL-1 can be harmful in chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease


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