ACTH (1-10) Human 1mg SYSMEHFRWG-acid
Description
Application Data
Description
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Segment 1-10 of adrenocorticotropic hormone (ACTH). ACTH, also known as corticotropin, is a cleavage product from a larger precursor proopiomelanocortin (POMC). This 39 amino acid-peptide hormone is produced in the anterior pituitary gland upon stimulation by the corticotropin releasing hormone from the hypothalamus in response to stress. It stimulates the secretion of steroid hormone, specifically… Read more »
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1000073j Molecular Weight 1299.41 Sequence (one letter code) SYSMEHFRWG-acid Sequence (three letter code) H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-OH
Purity >95% Storage This material should be stored below 0 degrees C References Stewart, PM. et al. Clin Endocrinol 40, 199 (1994)
Elias, LL. and AJ. Clark, Braz J Med Biol Res 33, 1245 (2000)
Latronico, AC. Braz J Med Biol Res 33, 1249 (2000)Manufactured in: United Kingdom Segment 1-10 of adrenocorticotropic hormone (ACTH). ACTH, also known as corticotropin, is a cleavage product from a larger precursor proopiomelanocortin (POMC). This 39 amino acid-peptide hormone is produced in the anterior pituitary gland upon stimulation by the corticotropin releasing hormone from the hypothalamus in response to stress. It stimulates the secretion of steroid hormone, specifically glucocorticoids in the adrenal cortex by acting through a cell membrane receptor (ACTH-R). In mammals, the action of ACTH is limited to those areas of the adrenal cortex in which the glucocorticoid hormones cortisol (hydrocortisone) and corticosterone are formed. ACTH has little control over the secretion of aldosterone, the other major steroid hormone from the adrenal cortex