Acetyl-alpha-MSH Heavy
Acetyl-SYSMEH-[U-13C9,15N-Phe]-RWGKPV-amide
Description
Application Data
Description
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Alpha-melanocyte stimulating hormone (α-MSH) is a non-selective agonist of melanocortin receptors involved in metabolic and immune homeostasis. Contains a phenylalanine residue labelled with 13C and 15N stable isotopes.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1301033 Molecular Weight 1673.8 Sequence (one letter code) Acetyl-SYSMEH-[U-13C9,15N-Phe]-RWGKPV-amide
Sequence (three letter code) Acetyl-Ser-Tyr-Ser-Met-Glu-His-[U-13C9,15N-Phe]-Arg-Trp-Gly-Lys-Pro-Val-NH2
Purity >95% Storage -20°C References Vecsernyes et al., (2017). Alpha–Melanocyte-stimulating Hormone Induces Vasodilation and Exerts Cardioprotection Through the Heme-Oxygenase Pathway in Rat Hearts. J. Cardiovasc. Pharmacol., 69(5): 286. PMID: 28195947.
Taylor (2013). Alpha-Melanocyte Stimulating Hormone (α-MSH) Is a Post-Caspase Suppressor of Apoptosis in RAW 264.7 Macrophages. PLoS ONE, 8(8): e74488. PMID: 24009773.
Capsoni et al., (2015). α-Melanocyte-stimulating-hormone (α-MSH) modulates human chondrocyte activation induced by proinflammatory cytokines. BMC Musculoskelet. Disord., 16(1). PMID: 26093672.
Manufactured in: United Kingdom Alpha-melanocyte stimulating hormone (α-MSH) is a melanocortin family neuropeptide which plays important roles in metabolic and immune homeostasis. It is formed from the cleavage of adrenocorticotropic hormone, the cleavage product of proopiomelanocortin hormone. α-MSH is expressed ubiquitously to varying degrees in a wide variety of cells including the hypothalamus, monocytes and retinal pigment epithelial cells. α-MSH is a non-selective agonist of melanocortin receptors.
α-MSH is a suppresser of inflammation from both innate and adaptive immune pathways, it is involved in hair and skin pigmentation (through MC1 receptor activation), has reproductive functions, cardio protective functions and regulates food intake and energy metabolism.
The phenylalanine residue at position 7 of this peptide is isotopically labelled with carbon-13 (9) and nitrogen-15 (1), giving this peptide a mass increase of 10 compared to the unlabelled peptide. The N-terminal of the peptide is protected by an acetyl group.