An antimicrobial peptide (AMP) which can inhibit in vitro binding of a cell surface adhesin of Streptococcus mutans to salivary receptors.
Catalogue number crb1000026 Molecular Weight 2202.46 Sequence (one letter code) Ac-QLKTADLPAGRDETTSFVLV-amide Sequence (three letter code) Ac-Gln-Leu-Lys-Thr-Ala-Asp-Leu-Pro-Ala-Gly-Arg-Asp-Glu-Thr-Thr-Ser-Phe-Val-Leu-Val-NH2 Molecular Weight 2202.46 Purity >95% Storage - 20 ° C References 1. C G CG Kelly et. al Nature Biotechnology, 17(1), 42-47 (1999) 2. Yakubovics, N. et al. Mol. Biol. 55, 1591 (2005)
Bacterial cell invasion begins by initially adhering to mucosa of the oro-intestinal, nasorespiratory, or genitourinary tract by specific adhesins. This leads to colonization of the region and ultimately infection. Studies showed acetyl-adhesin can inhibit binding of S. mutans to salivary receptors and can prevent S. mutans colonising the teeth. This suggests the peptide may be a useful antimicrobial agent against bacterial mucosal colonisation, particularly tooth decay.