An antimicrobial peptide (AMP) which can inhibit in vitro binding of a cell surface adhesin of Streptococcus mutans to salivary receptors.
Catalogue number crb1000026 Molecular Weight 2202.46 Sequence (one letter code) Ac-QLKTADLPAGRDETTSFVLV-amide Sequence (three letter code)
Purity >95% Storage - 20 ° C References
Hassan et al., (2012). Natural antimicrobial peptides from bacteria: characteristics and potential applications to fight against antibiotic resistance. J. Appl. Microbiol. 113(4): 723. https://doi.org/10.1111/j.1365-2672.2012.05338.
Kelly et al., (1999). A synthetic peptide adhesion epitope as a novel antimicrobial agent. Nat. Biotechnol. 55: 42. https://doi.org/10.1038/5213.
Manufactured in: United Kingdom
Bacterial cell invasion begins by initially adhering to mucosa of the oro-intestinal, nasorespiratory, or genitourinary tract by specific adhesins. This leads to colonization of the region and ultimately infection. Studies showed acetyl-adhesin can inhibit binding of S. mutans to salivary receptors and can prevent S. mutans colonising the teeth. This suggests the peptide may be a useful antimicrobial agent against bacterial mucosal colonisation, particularly tooth decay.