• Description

  • Application Data


Fluorogenic substrate for assaying proteasome activity. Contains a Rhodamine 110 molecule which will fluoresce upon peptide hydrolysis

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Application Data

Catalogue number crb1101107
Molecular Weight 851.3
Sequence (one letter code)


Sequence (three letter code)

Ac-GPLD-[Rh110]-[D-Pro], Where Rh110 is Rhodamine 110

Purity >95%

Banerjee et al., (2019). Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression. PNAS USA. 116(49): 24881. PMID: 31754034

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Fluorogenic substrate peptide to assay the caspase-like peptidic activity of the 20S proteasome. In its intact state this peptide is non-fluorescent, however when the Rhodamine fluorophore is released upon hydrolysation, fluorescence can be detected. This peptide is therefore a useful tool for analysing enzyme activity.

The presence of the D-proline residue on the C terminal of the rhodamine molecule ensures one directional rhodamine cleavage which simplifies fluorescence studies. Rhodamine 110 is a laser grade fluorescent dye with excitation maxima at 496 nm and emission maxima at 522 nm


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