• Description

  • Application Data


Ac-Arg-Gly-Lys(Ac)-AMC is a substrate peptide for histone deacetylase (HDAC) enzymes for use in assaying HDAC activity.

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Application Data

Catalogue number crb1101637
Molecular Weight 600.3
Sequence (one letter code)


Purity >95%
cas 660846-97-9

Hesping et al., (2020). An ELISA method to assess HDAC inhibitor-induced alterations to P. falciparum histone lysine acetylation. Int J Parasitol Drugs Drug Resist. 14: 249. PMID: 33279862.


Milazzo et al., (2020). Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability. Genes (Basel). 11(5): 556. PMID: 32429325.

Material Safety Data Sheet (MSDS)

Histone deacetylases (HDACs) are a family of enzymes which are highly evolutionary conserved across all eukaryotes. HDACs modify histones by removing acetyl groups from the tail regions. Histone deacetylation is generally associated with reduced gene expression due to a more compact chromatin state less accessibility for transcription factors (TFs). HDACs are essential for many physiological processes including development and cellular homeostasis. They also play an important role in disease states, including neurodegenerative disorders, genetic diseases and cancers.

This peptide is the fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin. Fluorescence can be detected upon fluorophore release.


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