[5-FAM]-Substance P [5-FAM]-RPKPQQFFGLM-NH2

  • Description

  • Application Data


[5-FAM]-Substance P is comprised of 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag and Substance P. Substance P is a neurokinin 1 receptor (NK1R) agonist with affinity for other neurokinin receptors. It is a highly conserved peptide with neurological, nociceptive, inflammatory and cell proliferation roles.

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Application Data

Catalogue number crb1100555
Molecular Weight 1704.8
Sequence (one letter code) [5-FAM]-RPKPQQFFGLM-NH2
Sequence (three letter code) [5-FAM]-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Purity >95%

Mashaghi et al (2016) Neuropeptide substance P and the immune response. Cell. Mol. Life Sci. 73(22) 4249 PMID 27314883

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Substance P (SP) is a peptide that is highly conserved across the animal kingdom and is involved in a number of inflammatory and growth promoting processes. SP has a net positive charge at physiological pH, it is an amphiphilic peptide with positively charged residues at the N-terminus and hydrophobic residues at the C-terminus, this controls how it interacts with cell membranes. SP is relatively stable in plasma (several hours) but has a short half-life in tissues (seconds/minutes).

SP is encoded by the TAC1 gene and is a member of the tachykinin peptide hormone family. SP is expressed by many cell types including: neurons; astrocytes; microglia; epithelial cells; endothelial cells; immune cells such as T cells and macrophages; dendritic cells and eosinophils and some stem cells and progenitor cells. The huge variety of cell types expressing SP suggest it is involved in a wide variety of physiological and pathophysiological functions.

SP mediates its functions by interacting with members of the neurokinin (NK) family of G protein–coupled receptors with high selectivity. Among these, SP binds to NK1R with the highest affinity, this receptor is expressed in a wide range of tissue types.

[5-FAM]-Substance P contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.

[5-FAM]-Substance P

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