• Description

  • Application Data


Cell-penetrating peptide derived from the murine sequence of the cell-adhesion molecule vascular endothelialcadherin, labelled at the N-terminus with fluorescein

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Application Data

Catalogue number crb1100281
Molecular Weight 2567.01
Sequence (one letter code) [5-FAM]-LLIILRRRIRKQAHAHSK-amide
Sequence (three letter code)


Purity >95%

Stalmans et al., (2015). Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo. PLoS One. 10(10): e0139652. PMID: 26465925


dos Santos Rodrigues et al., (2019). Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties. Int J Nanomedicine. 14: 6497–6517. PMID: 31616141

Data Sheet Material Safety Data Sheet (MSDS)

Cell-penetrating peptides (CPPs) have the ability to cross cell membrane bilayers without causing lethal membrane damage. CPPs themselves can exert biological activity and can be formed endogenously, or alternatively they can enhance transport of different cargoes across cell membranes.

Vascular endothelial-cadherin-derived peptide (pVec) is an amphipathic CPP, these are characterised by both hydrophobic and hydrophilic regions. The charged region interacts with the cell membrane, while the hydrophobic region causes membrane perturbation, enabling translocation. pVec is derived from vascular endothelial cadherin, which is able to cross the blood brain barrier.

Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.


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