[5-FAM]-MAP [5-FAM]-KLALKLALKALKAALKLA-amide

  • Description

  • Application Data

Description

Alpha helical amphipathic model peptide (MAP) labelled at the N-terminus with fluorescein

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Application Data

Catalogue number crb1100286
Molecular Weight 2234.76
Sequence (one letter code) [5-FAM]-KLALKLALKALKAALKLA-amide
Sequence (three letter code) [5-FAM]-Lys-Leu-Ala-Leu-Lys-Leu-Ala-Leu-Lys-Ala-Leu-Lys-Ala-Ala-Leu-Lys-Leu-Ala-NH2
Molecular Weight 2234.76
Purity >95%
References

Mant et al., (2019). De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii. J Med Chem. 62(7): 3354. PMID: 30848594

 

Kerth et al., (2004). Infrared Reflection Absorption Spectroscopy of Amphipathic Model Peptides at the Air/Water Interface. Biophys J. 86(6): 3750. PMID: 15189871

Data Sheet Material Safety Data Sheet (MSDS)

Amphipathic α-helical cationic antimicrobial peptides (AMPs) are rapidly bactericidal and have broad spectrum activity. As AMPs have non-specific modes of action involving membrane disruption, bacteria are less likely to develop resistance to them (unlike traditional antibiotics).

KLAL is a model compound to form amphipathic helices that are able to bind to membranes and increase the membrane permeability. KLAL model peptides may also form a β-structure under appropriate conditions.

Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.

[5-FAM]-MAP

Cat No.Pack SizePriceQty.
1mg£170.00
0.5mg£110.00
0.1mg£85.00
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