• Description

  • Application Data


Glucagon-like peptide (GLP)-1 is a gastrointestinal peptide hormone with a role in insulin secretion, and contains N-terminal fluorescent tag 5-Carboxyfluorescein (5-FAM).

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Application Data

Catalogue number crb1100880
Molecular Weight 4467.1
Sequence (one letter code)


Sequence (three letter code)


Purity >95%
Storage -20°C

Graaf et al (2016) Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes. Pharmacol. Rev. 68(4) 954 PMID: 27630114

Manandhar and Ahn (2014) Glucagon-like Peptide-1 (GLP-1) Analogs: Recent Advances, New Possibilities, and Therapeutic Implications. J. Med. Chem. 58(3) 1020 PMID: 25349901

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Glucagon-like peptide (GLP)-1 is a gastrointestinal peptide hormone with multiple roles in relation to metabolism. The primary role of GLP-1 is increasing insulin secretion in the presence of high plasma glucose levels, in addition, GLP-1 also suppresses glucagon secretion from the pancreas. GLP-1 slows down gastric emptying and regulates appetite, both valuable in reducing food intake and body weight. These roles of GLP-1 make it a useful target in the management of type 2 diabetes mellitus (T2DM).

GLP-1 exerts its effects by binding to and activating the class B G protein–coupled receptor (GPCR):  GLP-1 receptor (GLP-1R). Receptor activation in turn activates signalling pathways which culminates in insulin secretion via CAMP and Ca2+ signalling.

Recently evidence has increased for GLP-1 playing a cardio-protective role as well as regulating immune responses and even in kidney function. GLP-1 may also exert neuroprotective and neurotropic effects as it can decrease endogenous levels of amyloid-beta (Aβ) and prevent Aβ-induced cell death.

This peptide contains N-terminal 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.



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