[Aurora™ Fluor 647]-RGD peptide [Aurora™ Fluor 647]-GRGDSC-acid
The Arg-Gly-Asp (RGD) peptide is an adhesive motif allowing attachment to the extracellular matrix (ECM). It is labelled with the Aurora™ Fluor 647 fluorescent tag.
Catalogue number crb1101636 Purity >95% Storage -20°C References
Bellis (2011). Advantages of RGD peptides for directing cell association with biomaterials. Biomaterials. 32(18): 4205. https://doi.org/10.1016/j.biomaterials.2011.02.029.
Garanger et al., (2007). Tumor targeting with RGD peptide ligands-design of new molecular conjugates for imaging and therapy of cancers. Anticancer Agents Med Chem. 7(5): 552. doi: 10.2174/187152007781668706.
The RGD motif has been found in wide range of eukaryotic proteins allowing cell adhesion to the ECM. The tripeptide RGD is the primary domain to bind integrin found in extracellular matrix (ECM) proteins including fibronectin, fibrinogen and osteopontin. It has been shown to effectively adhere various cell types to a wide range of biomaterials. This is a key research tool in the flourishing area of tissue engineering and wound healing using synthetic peptides that are either inert or can be potentially beneficial. RGD is a suitable ligand for targeting nanomolecules and cancer drugs to specific tissues due to its biocompatibility and safety.
This RGD peptide is supplied with an Aurora™ Fluor 647 fluorophore attached and produced to research grade quality. Aurora™ Fluor 647 excitation suited to 594nm and emission peaked at 671nm.The Molecular Probes Alexa Fluor® dyes provide a number of benefits including: more intense fluorescence than other spectrally similar conjugates; better photostability, allowing more time for image capture; availability of conjugates in an array of distinct fluorescent colours from blue to infrared; and pH insensitivity that enables the dyes to remain highly fluorescent over a broad pH range; and high water solubility.