SOX2 peptide
Description
Application Data
Description
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Antigenic peptide from the master transcriptional regulator SOX2 which plays an essential role during mammalian embryogenesis
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1200402 Antibody SOX2 peptide Antigen Peptide SOX2 peptide Protein ID UniProtKB - P48431 Aliases Transcription Factor SOX-2, Sex Determining Region Y-Box, SRY-Box Cross-Reactivity Human Target Protein Species Human Storage Stabilisers -20°C Specificity Protein Storage -20°C Citations Rothenberg, S., Concannon, K., Cullen, S., Boulay, G., Turke, A., Faber, A., Lockerman, E., Rivera, M., Engelman, J., Maheswaran, S. and Haber, D. (2015). Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways. eLife, 4. PMID: 25686219
Wuebben, E. and Rizzino, A. (2017). The dark side of SOX2: cancer - a comprehensive overview. Oncotarget, 8(27). PMID: 28388544
References Rothenberg, S., Concannon, K., Cullen, S., Boulay, G., Turke, A., Faber, A., Lockerman, E., Rivera, M., Engelman, J., Maheswaran, S. and Haber, D. (2015). Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways. eLife, 4. PMID: 25686219
Wuebben, E. and Rizzino, A. (2017). The dark side of SOX2: cancer – a comprehensive overview. Oncotarget, 8(27). PMID: 28388544
The pluripotency-associated master transcriptional regulator SOX2 is essential during mammalian embryogenesis, embryonic stem cell maintenance and later in life, however SOX2 expression can also be highly detrimental. SOX2 has been shown to be expressed in at least 25 different cancers, consequently, too little or too much SOX2 can dramatically alter tumour growth. SOX2 is therefore tightly regulated at the transcriptional level, by microRNAs, long non-coding RNAs, and post-translational modifications.
SOX2 represses the expression of pro-apoptotic molecules that mediate cell death following oncogene withdrawal in these cells. The induction of SOX2 results from the activation of FOXO6, a forkhead family transcription factor following EGFR inhibition. SOX2 may therefore be a valuable target for cancer therapy.