mGluR1 peptide
Description
Application Data
Description
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Antigenic peptide from metabotropic glutamate receptor 1, a G protein-coupled receptor involved in glutamate neurotransmission
Application Data
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Catalogue number crb1200278 Antibody mGluR1 peptide Antigen Peptide mGluR1 peptide Protein ID UniProtKB - Q13255 Aliases GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13, glutamate metabotropic receptor 1, protein phosphatase 1 regulatory subunit 85 Cross-Reactivity Rat, Mouse (predicted Horse) Target Protein Species Rat, Mouse (predicted Horse) Storage Stabilisers -20°C Family G-protein coupled receptor 3 family Disease Area Neurodegenerative diseases Specificity Protein Storage -20°C Citations Bakshi, K., Parihar, R., Goswami, S., Walsh, M., Friedman, E. and Wang, H. (2014). Prenatal Cocaine Exposure Uncouples mGluR1 from Homer1 and Gq Proteins. PLoS ONE, 9(3), e91671. PMID: 24626340
Lopez-Chiriboga, A., Komorowski, L., Kümpfel, T., Probst, C., Hinson, S., Pittock, S. and McKeon, A. (2016). Metabotropic glutamate receptor type 1 autoimmunity. Neurology, 86(11), 1009-1013. PMID: 26888994
References Bakshi, K., Parihar, R., Goswami, S., Walsh, M., Friedman, E. and Wang, H. (2014). Prenatal Cocaine Exposure Uncouples mGluR1 from Homer1 and Gq Proteins. PLoS ONE, 9(3), e91671. PMID: 24626340
Lopez-Chiriboga, A., Komorowski, L., Kümpfel, T., Probst, C., Hinson, S., Pittock, S. and McKeon, A. (2016). Metabotropic glutamate receptor type 1 autoimmunity. Neurology, 86(11), 1009-1013. PMID: 26888994
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that have been divided into three groups based on sequence, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 is a group I receptor. Group I mGluRs are predominantly expressed in the postsynaptic somatodendritic regions, especially in brain areas highly responsive to psychostimulants. mGluR1 is a pivotal regulator of glutamatergic neurotransmission which is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.
Group I mGluRs are coupled exclusively to Gq protein (Gq/11), a heterotrimeric G protein subunit that activates phospholipase C (PLC) and regulates inositol 1,4,5-tris phosphate (IP3) receptors via association with the synaptic scaffolding protein, homer.
mGluRs modulate neuronal excitability and development, synaptic plasticity and neurotransmitter release underlying optimal cognitive function. Activation of mGluR1 facilitates long-term depression of parallel fiber–Purkinje cell synapses critical for cerebellar motor learning.