KA1 peptide
Description
Application Data
Description
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Antigenic peptide of KA1, a kainate glutamate receptor involved in memory and behaviour
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1200001 Antibody KA1 peptide Antigen Peptide KA1 peptide Protein ID UniProtKB - Q01812 Aliases Glutamate receptor ionotropic, kainate 4, Grik4, GluK4, KA1, Glutamate receptor KA-1, KA-1 Cross-Reactivity Mouse, rat Target Protein Species Mouse, rat Storage Stabilisers -20°C Specificity Protein Storage -20°C Citations Fernandes, H., Catches, J., Petralia, R., Copits, B., Xu, J., Russell, T., Swanson, G. and Contractor, A. (2009). High-Affinity Kainate Receptor Subunits Are Necessary for Ionotropic but Not Metabotropic Signaling. Neuron, 63(6), 818-829. PMID: 19778510
Knight, H., Walker, R., James, R., Porteous, D., Muir, W., Blackwood, D. and Pickard, B. (2011). GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status. Am J Med Genet B: Neuropsychiatr Genet, 159B(1), 21-29. PMID: 22052594
References Fernandes, H., Catches, J., Petralia, R., Copits, B., Xu, J., Russell, T., Swanson, G. and Contractor, A. (2009). High-Affinity Kainate Receptor Subunits Are Necessary for Ionotropic but Not Metabotropic Signaling. Neuron, 63(6), 818-829. PMID: 19778510
Knight, H., Walker, R., James, R., Porteous, D., Muir, W., Blackwood, D. and Pickard, B. (2011). GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status. Am J Med Genet B: Neuropsychiatr Genet, 159B(1), 21-29. PMID: 22052594
Glutamate is the principal excitatory neurotransmitter in the central nervous system (CNS), and imbalances in glutamatergic transmission have profound behavioural and physiological consequences. KA1 is a kainate receptor, which are atypical members of the glutamate receptor family able to signal through both ionotropic and metabotropic pathways. KA1 plays a role in memory and behaviour, and aberrant KA1 expression is seen in neurodegeneration, schizophrenia and bipolar disorder.
The KA1 subunit shows very limited and well-defined expression in just a few neuronal cell types after birth. In the hippocampus KA1 mRNA is expressed at high levels in the CA3 pyramidal neurons and at very low levels in granule cells in the dentate gyrus. In all other neurons in the hippocampus, KA1 is absent.