KA1 peptide

  • Description

  • Application Data

Description

Antigenic peptide of KA1, a kainate glutamate receptor involved in memory and behaviour

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Application Data

Catalogue number crb1200001
Antibody KA1 peptide
Antigen Peptide KA1 peptide
Protein ID UniProtKB - Q01812
Aliases Glutamate receptor ionotropic, kainate 4, Grik4, GluK4, KA1, Glutamate receptor KA-1, KA-1
Cross-Reactivity Mouse, rat
Target Protein Species Mouse, rat
Storage Stabilisers -20°C
Specificity Protein
Storage -20°C
Citations

Fernandes, H., Catches, J., Petralia, R., Copits, B., Xu, J., Russell, T., Swanson, G. and Contractor, A. (2009). High-Affinity Kainate Receptor Subunits Are Necessary for Ionotropic but Not Metabotropic Signaling. Neuron, 63(6), 818-829. PMID: 19778510

 

Knight, H., Walker, R., James, R., Porteous, D., Muir, W., Blackwood, D. and Pickard, B. (2011). GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status. Am J Med Genet B: Neuropsychiatr Genet, 159B(1), 21-29. PMID: 22052594

References

Fernandes, H., Catches, J., Petralia, R., Copits, B., Xu, J., Russell, T., Swanson, G. and Contractor, A. (2009). High-Affinity Kainate Receptor Subunits Are Necessary for Ionotropic but Not Metabotropic Signaling. Neuron, 63(6), 818-829. PMID: 19778510

 

Knight, H., Walker, R., James, R., Porteous, D., Muir, W., Blackwood, D. and Pickard, B. (2011). GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status. Am J Med Genet B: Neuropsychiatr Genet, 159B(1), 21-29. PMID: 22052594

Data Sheet Material Safety Data Sheet (MSDS)

Glutamate is the principal excitatory neurotransmitter in the central nervous system (CNS), and imbalances in glutamatergic transmission have profound behavioural and physiological consequences. KA1 is a kainate receptor, which are atypical members of the glutamate receptor family able to signal through both ionotropic and metabotropic pathways. KA1 plays a role in memory and behaviour, and aberrant KA1 expression is seen in neurodegeneration, schizophrenia and bipolar disorder.

The KA1 subunit shows very limited and well-defined expression in just a few neuronal cell types after birth. In the hippocampus KA1 mRNA is expressed at high levels in the CA3 pyramidal neurons and at very low levels in granule cells in the dentate gyrus. In all other neurons in the hippocampus, KA1 is absent.

KA1 peptide

Cat No.Pack SizePriceQty.
100µg£85.00
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