JAK2 peptide
Description
Application Data
Description
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Antigenic peptide of human JAK2, a non-receptor tyrosine kinase involved in immunity, cell division, cell death and tumour formation
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1200012 Antibody JAK2 peptide Antigen Peptide JAK2 peptide Protein ID UniProtKB - O60674 Aliases Tyrosine-protein kinase JAK2, JAK-2, Janus kinase 2 Cross-Reactivity Human Target Protein Species Human Storage Stabilisers -20°C Specificity Protein Storage -20°C Citations Jay, J., Hammer, A., Nestor-Kalinoski, A. and Diakonova, M. (2014). JAK2 Tyrosine Kinase Phosphorylates and Is Negatively Regulated by Centrosomal Protein Ninein. Mol Cell Biol, 35(1), 111-131. PMID:25332239
Liu, C., Yang-Yen, H., Suen, C., Hwang, M. and Yen, J. (2017). Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction. Sci Rep, 7(1). PMID: 28676638
Trivedi, S. and Starz-Gaiano, M. (2018). Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis. Int J Mol Sci, 19(12), 4056. PMID: 30558204
References Jay, J., Hammer, A., Nestor-Kalinoski, A. and Diakonova, M. (2014). JAK2 Tyrosine Kinase Phosphorylates and Is Negatively Regulated by Centrosomal Protein Ninein. Mol Cell Biol, 35(1), 111-131. PMID:25332239
Liu, C., Yang-Yen, H., Suen, C., Hwang, M. and Yen, J. (2017). Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction. Sci Rep, 7(1). PMID: 28676638
Trivedi, S. and Starz-Gaiano, M. (2018). Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis. Int J Mol Sci, 19(12), 4056. PMID: 30558204
Janus kinase-2 (JAK2) is a non-receptor tyrosine kinase implicated in signalling via members of the type II cytokine receptor family (such as interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R). The JAK/signal transducer and activator of transcription (STAT) pathway is a key cellular pathway which is involved in immunity, cell division, cell death and tumour formation. The JAK/STAT pathway is activated by leptin and the leptin receptor and results in phosphorylation of STAT3 and its translocation to the nucleus where it activates the transcription of various target genes.
Mutations and gene fusions involving JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders and leukaemia