IL-11 peptide
Description
Application Data
Description
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Antigenic peptide from IL-11, a multifunctional haematopoietic cytokine implicated in several normal and pathological processes
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1200323 Antibody IL-11 peptide Antigen Peptide IL-11 peptide Protein ID UniProtKB - P20809 Aliases Interleukin-11, adipogenesis inhibitory factor Cross-Reactivity Human Target Protein Species Human Storage Stabilisers -20°C Specificity Protein Storage -20°C Citations Tao, L., Huang, G., Wang, R., Pan, Y., He, Z., Chu, X., Song, H. and Chen, L. (2016). Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway. Sci Rep, 6(1). PMID: 27922075
Sokolov, A., Kazakov, A., Solovyev, V., Ismailov, R., Uversky, V., Lapteva, Y., Mikhailov, R., Pavlova, E., Terletskaya, I., Ermolina, L., Permyakov, S. and Permyakov, E. (2016). Expression, Purification, and Characterization of Interleukin-11 Orthologues. Molecules, 21(12), 1632. PMID: 27916836
References Tao, L., Huang, G., Wang, R., Pan, Y., He, Z., Chu, X., Song, H. and Chen, L. (2016). Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway. Sci Rep, 6(1). PMID: 27922075
Sokolov, A., Kazakov, A., Solovyev, V., Ismailov, R., Uversky, V., Lapteva, Y., Mikhailov, R., Pavlova, E., Terletskaya, I., Ermolina, L., Permyakov, S. and Permyakov, E. (2016). Expression, Purification, and Characterization of Interleukin-11 Orthologues. Molecules, 21(12), 1632. PMID: 27916836
Interleukin-11 (IL-11) is a multifunctional haematopoietic cytokine implicated in several normal and pathological processes. It belongs to the interleukin-6 (IL-6) family of cytokines, which affect intracellular signalling pathways via interaction with the ubiquitously expressed signal-transducing receptor, gp130 and a non-signalling cytokine-specific receptor.
IL-11 is expressed in hepatocytes, B cells, macrophages and osteoclasts and it activates JAK/STAT and MAPK signalling pathways, exerting in some cases drastically different physiological effects. IL-11 favours oncogenesis in numerous overlapping cancer types such as gastrointestinal cancers, breast cancer and osteosarcoma. IL-11 has growth factor activity, immunological activity and plays a role in female fertility control. IL-11 is under investigation for treatment of rheumatoid arthritis, Crohn’s disease, and other inflammatory conditions.