HAND1 peptide
Description
Application Data
Description
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Antigenic peptide of HAND1, a twist family bHLH transcription factor essential for several developmental processes
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1200298 Antibody HAND1 peptide Antigen Peptide HAND-1 peptide Protein ID UniProtKB - O96004 Cross-Reactivity Human, mouse, rat Target Protein Species Human, mouse, rat Storage Stabilisers -20°C Specificity Protein Storage -20°C Citations Barnes, R. and Firulli, A. (2009). A twist of insight - the role of Twist-family bHLH factors in development. Int J Dev Biol, 53(7), 909-924. PMID: 19378251
Firulli, B., Fuchs, R., Vincentz, J., Clouthier, D. and Firulli, A. (2014). Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development, 141(15), 3050-3061. PMID: 25053435
References Barnes, R. and Firulli, A. (2009). A twist of insight – the role of Twist-family bHLH factors in development. Int J Dev Biol, 53(7), 909-924. PMID: 19378251
Firulli, B., Fuchs, R., Vincentz, J., Clouthier, D. and Firulli, A. (2014). Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development, 141(15), 3050-3061. PMID: 25053435
Heart and neural crest derivatives expressed 1 (HAND1) is a basic helix-loop-helix (bHLH) transcription factor belonging to the twist family. Twist-family transcription factors play essential roles in a number of developmental programs and function by dimerising with other bHLH members and binding to cis- regulatory elements, called E-boxes. HAND1 can form homodimers as well as interact with other tissue restricted bHLH proteins, such as HAND2. Dimer partner choice infers differential regulation on twist family proteins and is regulated by phosphorylation. Protein Kinase A and C (PKA and PKC) can phosphorylate HAND1, while β56δ-containing protein phosphatase 2A (PP2A) can dephosphorylate HAND1.
HAND1 is required for proper cardiac morphogenesis and is essential for extra-embryonic and trophoblast cell differentiation. Hand1 is expressed in several foetal tissues and in adult heart tissue where it may have a role in preventing hypertrophy.