GLT-1 peptide
Description
Application Data
Description
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Antigenic peptide of GLT1, the major glutamate transporter in the mammalian brain
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1200000 Antibody GLT-1 peptide Antigen Peptide GLT-1 peptide Protein ID UniProtKB - P43006, P31596 Aliases GLT1, EAAT2 , Excitotoxic Amino Acid Transporter 2, Excitatory Amino Acid Transporter 2, Solute Carrier Family 1 Member 2, Sodium-Dependent Glutamate/Aspartate Transporter 2, Glutamate/Aspartate Transporter II Cross-Reactivity Human, mouse Target Protein Species Human, mouse Storage Stabilisers -20°C Specificity Protein Storage -20°C Citations Al Awabdh, S., Gupta-Agarwal, S., Sheehan, D., Muir, J., Norkett, R., Twelvetrees, A., Griffin, L. and Kittler, J. (2016). Neuronal activity mediated regulation of glutamate transporter GLT-1 surface diffusion in rat astrocytes in dissociated and slice cultures. Glia, 64(7), 1252-1264. PMID: 27189737
Meabon, J., Lee, A., Meeker, K., Bekris, L., Fujimura, R., Yu, C., Watson, G., Pow, D., Sweet, I. and Cook, D. (2011). Differential Expression of the Glutamate Transporter GLT-1 in Pancreas. J Histochem Cytochem, 60(2), 139-151. PMID: 22114258
References Al Awabdh, S., Gupta-Agarwal, S., Sheehan, D., Muir, J., Norkett, R., Twelvetrees, A., Griffin, L. and Kittler, J. (2016). Neuronal activity mediated regulation of glutamate transporter GLT-1 surface diffusion in rat astrocytes in dissociated and slice cultures. Glia, 64(7), 1252-1264. PMID: 27189737
Meabon, J., Lee, A., Meeker, K., Bekris, L., Fujimura, R., Yu, C., Watson, G., Pow, D., Sweet, I. and Cook, D. (2011). Differential Expression of the Glutamate Transporter GLT-1 in Pancreas. J Histochem Cytochem, 60(2), 139-151. PMID: 22114258
Glutamate transporter 1 (GLT-1) is the major glutamate transporter in the brain, and is predominantly expressed in astrocytes, but at lower levels also in excitatory terminals. GLT-1 is best understood for its critical role in preventing neuronal excitotoxicity and brain seizures in the central nervous system (CNS). Maintaining the correct level of extracellular glutamate is crucial for neuronal transmission and network activity.
Glutamate uptake function allows GLTs/EAATs to terminate and shape excitatory synaptic transmission, and prevent neuronal excitotoxicity. Increasing evidence argues that GLT-1 also modulates, and is modulated by, metabolic processes that influence glucose homeostasis.