FGFR2c peptide
Description
Application Data
Description
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Antigenic peptide of fibroblast growth factor receptor 2c mesenchymal splice variant
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1200371 Antibody FGFR2c peptide Antigen Peptide FGFR2c peptide Aliases Fibroblast growth factor receptor 2c, FGFR2c Cross-Reactivity Human Target Protein Species Human Storage Stabilisers -20°C Specificity Protein Storage -20°C Citations Pfaff, M., Xue, K., Li, L., Horowitz, M., Steinbacher, D. and Eswarakumar, J. (2016). FGFR2c-mediated ERK–MAPK activity regulates coronal suture development. Dev Biol, 415(2), 242-250. PMID: 27034231
Ranieri, D., Rosato, B., Nanni, M., Belleudi, F. and Torrisi, M. (2017). Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion. Mol Carcinog, 57(2), 272-283. PMID: 29068468
References Pfaff, M., Xue, K., Li, L., Horowitz, M., Steinbacher, D. and Eswarakumar, J. (2016). FGFR2c-mediated ERK–MAPK activity regulates coronal suture development. Dev Biol, 415(2), 242-250. PMID: 27034231
Ranieri, D., Rosato, B., Nanni, M., Belleudi, F. and Torrisi, M. (2017). Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion. Mol Carcinog, 57(2), 272-283. PMID: 29068468
The fibroblast growth factor receptor (FGFR) family consists of four transmembrane receptor tyrosine kinases (FGFR1‐4), which regulate important physiological processes, such as cell proliferation, differentiation, migration and survival throughout the body. FGFR2c is known as the mesenchymal FGFR2 isoform and when aberrantly expressed in epithelial cells it induces epithelial‐mesenchymal transition (EMT) and is involved in cancer progression.
FGFR2 signalling is critical for proper craniofacial development. A gain-of-function mutation in the 2c splice variant is associated with Crouzon syndrome, which is characterized by craniosynostosis, the premature fusion of one or more of the cranial vault sutures, leading to craniofacial maldevelopment. FGFR2c-mediated ERK-MAPK signalling is a key mediator of craniofacial growth and coronal suture development.