An antibody raised against pantetheinase; a mouse amidohydrolase, Vnn1 hydrolyses specifically one of the carboamide linkages in D-pantetheine recycling pantothenic acid (vitamin B5) and releasing cysteamine.
Catalogue number crb2005645 Antibody Anti-Vnn1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200854e Protein ID Q9Z0K8 Mouse Vnn1 Aliases Pantetheinase, Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, Vnn1 Cross-Reactivity Mouse Target Protein Species Mouse Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml Target Vnn1 Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Bartucci et al., (2019). Vanin 1: Its Physiological Function and Role in Diseases. Int J Mol Sci. 20(16): 3891. PMID: 31404995.
Hu et al., (2016). VNN1 promotes atherosclerosis progression in apoE−/− mice fed a high-fat/high-cholesterol diet. J Lipid Res. 57(8): 1398. PMID: 27281478.
Vascular non-inflammatory molecule-1 (Vanin-1/VNN1) is a membrane-associated glycosylphosphatidyl inositol (GPI)-anchored pantetheinase enzyme, highly expressed in many organs including the liver, gut and kidney. Vnn-1 catalyses the hydrolysis of pantetheine into cysteamine and pantothenic acid (vitamin B5); a precursor of coenzyme A.
Vnn-1 is involved in many pathways, including glycose metabolism; tissue tolerance to stress; oxidative stress and inflammation; malaria susceptibility; psoriasis; carcinogenesis; cardiovascular disease; asthma; paediatric immune thrombocytopenia, and systemic sclerosis. VNN1 attenuated Ox-LDL-induced apoptosis by upregulating p53 expression and downregulating B-cell lymphoma-2 expression.