Anti-VMP1 antibody
Description
Application Data
Description
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Antibody raised against VMP1, an endoplasmic reticulum (ER) transmembrane protein used lipid in homeostasis and regulation of autophagy though involvement in autophagosome biogenesis.
Application Data
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Data Sheet Data Sheet Data Sheet Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb2005690 Antibody Anti-VMP1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200899 Protein ID UniProtKB - Q96GC9 Aliases Vacuole membrane protein 1, Transmembrane protein 49, VMP1, TDC1, TMEM49 Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 1.0 mg/mL Glycine (R1G), 0.1 mg/mL TEA (R1T), 0.5 mg/mL Glycine (R2G), 0.2 mg/mL TEA (R2T) Target VMP1 Family VMP1 family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. Vacuole membrane protein 1 (VMP1) is an endoplasmic reticulum (ER) transmembrane protein, associated with a range of human diseases. Best known for its involvement in diseases such as pancreatitis and Alzheimer’s, VMP1 causes autophagy of cells when it is overexpressed. Through its binding to Beclin1, VMP1 is a key positive regulator of autophagy and is involved in the process of autophagosome generation. However, overexpression of VMP1 can form an excess of complexes, leading to excessive autophagosome generation; this causes the death of the cell regardless of the conditions the cell is under, be that favourable or adverse.
The ER is where most of the biosynthesis of structures within a cell takes place, with VMP1 being necessary in secretion of lipoproteins and autophagosomes from the ER into the cell matrix. Through interactions with BECN1 and ATP2A2, VMP1 controls the dissociation of autophagosomes from the ER, and plays a part in intracellular communication with other organelles.
VMP1 has the potential to be used in novel cancer treatments, through its involvement in autophagy of specific cellular components; however more research into this application is needed.