Antibody raised against Vegfb; a growth factor for endothelial cells.
Catalogue number crb2005694 Antibody Anti-Vegfb antibody Antigen Peptide KLH conjugated synthetic peptide crb1200903 Protein ID UniProtKB - P49766 Aliases Vascular endothelial growth factor B, Vegfb, VEGF-related factor Cross-Reactivity Mouse Host Species Rabbit Antibody Type Polyclonal Concentration 0.5mg/ml Glycine (R1G), 1mg/ml Glycine (R2G) Target Vegfb Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.
The vascular endothelial growth factor (VEGF) family comprises of VEGF-A, VEGF-B, VEGF-C, VEGF-D and placenta growth factor (PGF). This family of signal proteins are produced by a range of cells to stimulate the formation of blood vessels.
The biological functions of Vegfb are still relatively enigmatic; although not essential in inducing blood vessel growth, Vegfb appears to be critical in blood vessel survival. Vegfb treatment has been shown to protect endangered neurons from apoptosis without the need to induce undesired blood vessel growth or permeability. It is an important survival factor in a many cells; through inhibiting apoptotic genes and preventing cell death. Under certain conditions, Vegfb can act to inhibit tumour growth and promote angiogenesis.
Vegfb does not appear to have a direct involvement in angiogenesis, but rather an indirect role in vascular growth through effect on Vegfa action. Vegfb has also been shown to change gene expression of proteins involved in cardiac metabolism, promoting cell survival.