Anti-Vegfb antibody
Description
Application Data
Description
-
Antibody raised against Vegfb; a growth factor for endothelial cells.
Application Data
-
Material Safety Data Sheet (MSDS)Catalogue number crb2005657 Antibody Anti-Vegfb antibody Antigen Peptide KLH conjugated synthetic peptide crb1200866e Protein ID P49766 Vegfb Aliases Vascular endothelial growth factor B, Vegfb, VEGF-related factor Cross-Reactivity Mouse Target Protein Species Mouse Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml Glycine (R1G), 0.5mg/ml Glycine (R2G) Target Vegfb Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Family PDGF/VEGF growth factor family Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References Li, X., et al. (2009). VEGF-B. Cell Adhesion & Migration, 3(4), pp.322–327.
Olofsson, B., et al. (1999). Current biology of VEGF-B and VEGF-C. Current Opinion in Biotechnology, 10(6), pp.528–538.
Zhang, F., et al. (2009). VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proceedings of the National Academy of Sciences, 106(15), pp.6152–6157.
The vascular endothelial growth factor (VEGF) family comprises of VEGF-A, VEGF-B, VEGF-C, VEGF-D and placenta growth factor (PGF). This family of signal proteins are produced by a range of cells to stimulate the formation of blood vessels.
The biological functions of Vegfb are still relatively enigmatic; although not essential in inducing blood vessel growth, Vegfb appears to be critical in blood vessel survival. Vegfb treatment has been shown to protect endangered neurons from apoptosis without the need to induce undesired blood vessel growth or permeability. It is an important survival factor in a many cells; through inhibiting apoptotic genes and preventing cell death. Under certain conditions, Vegfb can act to inhibit tumour growth and promote angiogenesis.
Vegfb does not appear to have a direct involvement in angiogenesis, but rather an indirect role in vascular growth through effect on Vegfa action. Vegfb has also been shown to change gene expression of proteins involved in cardiac metabolism, promoting cell survival.