Antibody raised against UCP1; a mitochondrial protein used in adaptive thermogenesis and regulation of energy balance. Functions as long-chain fatty acid and proton symporter, allowing one LCFA & proton through the inner mitochondrial membrane.
Catalogue number crb2005656 Antibody Anti-UCP1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200865e Protein ID P25874 UCP1 Aliases Mitochondrial brown fat uncoupling protein 1, UCP 1, Solute carrier family 25 member 7, Thermogenin, SLC25A7 Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 2mg/ml Glycine (R1G), 2mg/ml Glycine (R2G) Target UCP1
Mitochondrial brown fat uncoupling protein 1 (UPC1) allows non-shivering thermogenesis to be undertaken in the brown adipose tissue. This occurs due to activation of UPC1 by long chain fatty acids causing an increase in conductance of H+ ions across the inner mitochondrial membrane. This increase in conductance causes brown adipose tissue mitochondria to generate heat, rather than ATP.
When compared with UCP2 and UCP3, UCP1 differs as its expression is positively correlated with metabolic inefficiency, and is increased by cold acclimation. Because of this UCP2/UCP3 cannot be used as UCP1 substitutes, any kind of cold acclimation-induced non-shivering thermogenesis is entirely dependent on the presence of UCP1.