An antibody raised against transient receptor potential ankyrin 1 (TRPA1); is highly expressed in pain-sensing neurons and tissues with a wide range of agonists that induce pain/inflammation.
Catalogue number crb2005732 Antibody Anti-TRPA1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200941 Protein ID UniProtKB - O75762 Aliases Transient receptor potential cation channel subfamily A member 1, Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120, Wasabi receptor Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 0.5 mg/ml Glycine (R1G), 0.2 mg/ml TEA (R1T), 0.2 mg/ml TEA (R2T) Target TRPA1 Family Transient receptor (TC 1.A.4) family. Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References
Souza Monteiro de Araujo et al., (2020). TRPA1 as a therapeutic target for nociceptive pain. Expert Opin. Ther. Targets, 24(10): 997. doi: 10.1080/14728222.2020.1815191.
Talavera et al., (2020). Mammalian transient receptor potential TRPA1 channels: from structure to disease. Physiol rev., 100(2): 725. doi: 10.1152/physrev.00005.2019.
Transient receptor potential ankyrin 1 (TRPA1) is a receptor-activated non-selective cation channel involved in pain detection. TRPA1 is activated by many structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues covalently. A cytosolic factor is required to keep TRPA1 in an agonist-sensitive state for activation by irritants such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, and diallyl disulfide (DADS). TRPA1 has been linked to numerous pain conditions and is a target for anti-inflammatory and analgesic therapies.
Inner ear function is also believed to be linked to TRPA1. TRPA1 acts as a component for the mechanosensitive transduction channel of hair cells in the inner ear, thereby participating in the perception of sounds.