An antibody raised against TAS2R39, a putative bitter taste receptor that interacts with bacterial molecules to activate the immune response.
Catalogue number crb2005723 Antibody Anti-TAS2R39 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200932 Protein ID UniProtKB - P59534 Aliases Taste receptor type 2 member 39, T2R39, Taste receptor type 2 member 57 (T2R57) Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 2.0 mg/ml Glycine (R1G), 0.2 mg/ml TEA (R1T), 2.0 mg/ml Glycine (R2G), 0.2 mg/ml TEA (R2T) Target TAS2R39 Family G-protein coupled receptor T2R family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References
Conte et al., (2003). Evolutionary relationships of the Tas2r receptor gene families in mouse and human. Physiol Genom., 14(1): 73. doi: 10.1152/physiolgenomics.00060.2003.
Gopallawa et al., (2021). Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling. Cell. Mol. Life Sci., 78: 271. doi: 10.1007/s00018-020-03494-y.
Bitter taste receptors (TAS2Rs) are predominantly found in the mouth and other tissues, including the gut and lungs, and cell types such as immune cells. Taste receptor type 2 member 39 (TAS2R39) is a receptor that plays a prominent role in the perception of bitterness. TAS2R39 may also play a role in sensing the chemical composition of the gastrointestinal content. The activity of the TAS2R39 receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. TAS2Rs recognise a wide variety of compounds, and work with TAS2R39 has helped identify antagonist compounds to block the perceived bitterness of medications. 6-methoxyflavanones are antagonists of TAS2R39, the methoxy group on the 6-position of the flavanone’s A-ring is the critical region for exerting inhibitory activity.
TAS2Rs recognise bacterial compounds such as acyl-homoserine lactones and are active in neurogenic inflammation and bacterial clearance for the upper airways. In the lungs, bronchial muscle contraction and cilia beating on epithelial cells are modulated by TAS2R receptor activation. TAS2R agonists can inhibit lung inflammation or smooth muscle contraction in asthma animal models.
This polyclonal antibody is reactive to the human TAS2R39; we also have an antibody to the mouse homolog Tas2r139 available here.